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GENTAUR NEWS 2009
Vitotox™ 10 kit
Genotoxicity and
Cytotoxcity test
The
GENTAUR
Vitotox™ 10 Kit is a unique method for rapid and cost
effective high-throughput genotoxicity and toxicity screening.
Two recombinant Salmonella typhimurium TA104 test strains
are used in the assay to determine simultaneously both genotoxicity and
cytotoxicity of the sample. The test is based on luciferase reporter gene
system which activity is measured by light emission and is a function of the
genotoxicity of the test compound. Normally, the luciferase reporter gene is
strongly repressed, but in the presence of a DNA damaging genotoxic compound
the initiation of a cascade of reactions known as the SOS response will take
place leading to derepression of the very strong promoter controlling the
luciferase gene.
Features
·
Very small amount of sample required
·
High reproducibility and sensitivity
·
Very good correlation with AMES test
·
Rapid answers in only 3 hours
·
Low labor costs; automatic reading of kinetic data
·
No test organism maintenance required |
One of the major benefits over the Ames test is that the
entire DNA content of the cell functions as a target for the genotoxin to
display its effect. In contrast, the Ames test monitors mutations only in
genes related to histidine synthesis. This results in a significantly lower
sample concentrations (up to 1000 fold) required for the Vitotox™ 10 Kit.
Code |
Product Name |
Number of samples |
Price |
04-6400-000 |
Vitotox 10 kit |
10 |
€
3,300 |
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To view our other products let us
invite you to visit our other websites like :
Gentaur /
Clonagen /
Genoprice / Bioxys /
Labprice
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