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GENTAUR NEWS 2009
PARP Pharmacodynamic Assay
PARP catalyzes the NAD-dependent addition of poly
(ADP-ribose) (PAR) onto itself and adjacent nuclear proteins. Furthermore,
polymorphisms in the PARP-1 gene correspond to disease predisposition, and
variation in PARP activity might have an impact on the effects of PARP
inhibitors in clinical settings. To address the need to monitor PARP
activity among different individuals, and within cells, validated
PARP in vivo Pharmacodynamic Assay
measures net PAR levels in cellular extracts and has been used to document
differences in PAR levels among tumor lysates from different tissues, organs
and xenografts.
|
Features
-
Chemiluminescent, non-radioactive format
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Higher throughput, 96 test size
-
Sensitivity down to 10 pg/ml of PAR |
|
Applications
-
Quantification of PAR in peripheral blood mononuclear cells and
tissue culture cells
-
Monitoring the efficacy of PARP inhibitors on cellular PAR formation
-
Verifying observations of enhanced cancer cell cytotoxicity arising
from PARP inhibitor/anticancer drug combination therapy. |
|
Code |
Product Name |
Quantity |
Price |
|
4510-096-K |
PARP in
vivo Pharmacodynamic Assay |
1x 96 well |
€
1.269 |
|
4690-096-K |
HT
Fluorescent Homogen. PARP Inhibition Assay |
1x 96 well |
€ 489 |
|
4684-096-K |
HT Colorimetric
PARP/Apoptosis Assay |
1x 96 well |
€
533 |
|
4685-096-K |
HT
Chemiluminescent PARP/Apoptosis Assay |
1x 96 well |
€
533 |
|
4683-096-K |
HT
Colorimetric PARG Assay Kit |
1x 96 well |
€
523 |
|
4682-096-K |
HT
Chemiluminescent PARG Assay Kit |
1x 96 well |
€
523 |
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