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GENTAUR NEWS 2009

 

PARP Pharmacodynamic Assay

Gentaur PARP Pharmacodynamic Assay 

PARP catalyzes the NAD-dependent addition of poly (ADP-ribose) (PAR) onto itself and adjacent nuclear proteins. Furthermore, polymorphisms in the PARP-1 gene correspond to disease predisposition, and variation in PARP activity might have an impact on the effects of PARP inhibitors in clinical settings. To address the need to monitor PARP activity among different individuals, and within cells, validated PARP in vivo Pharmacodynamic Assay measures net PAR levels in cellular extracts and has been used to document differences in PAR levels among tumor lysates from different tissues, organs and xenografts.

Features

 

-          Chemiluminescent, non-radioactive format

-          Higher throughput, 96 test size

-          Sensitivity down to 10 pg/ml of PAR

 

Applications

 

-          Quantification of PAR in peripheral blood mononuclear cells and tissue culture cells

-          Monitoring the efficacy of PARP inhibitors on cellular PAR formation

-          Verifying observations of enhanced cancer cell cytotoxicity arising from PARP inhibitor/anticancer drug combination therapy.

 

 

 

Code

Product Name

Quantity

Price

4510-096-K

PARP in vivo Pharmacodynamic Assay

1x 96 well

€ 1.269

4690-096-K

HT Fluorescent Homogen. PARP Inhibition Assay

1x 96 well

€ 489

4684-096-K

HT Colorimetric PARP/Apoptosis Assay

1x 96 well

€ 533

4685-096-K

HT Chemiluminescent PARP/Apoptosis Assay

1x 96 well

€ 533

4683-096-K

HT Colorimetric PARG Assay Kit

1x 96 well

€ 523

4682-096-K

HT Chemiluminescent PARG Assay Kit

1x 96 well

€ 523

 

Check also, our other products here.

 

 

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Last modified: 05/27/09